2:14 pm - 04/02/2012

Question about estrogen/progestin

Hey VPers!

This is a strange question, but it's confused me for a while.

I've read all over the place and heard that the estrogen part of combined birth control is what can cause blood clots and the risk of stroke and heart attack. Yet, on the Nuva-Ring commercial, it says that the progestin in Nuva-Ring is what can lead to blood clots and stroke, etc.

So what the heck???
That is really weird/confusing!
archangelbeth 2nd-Apr-2012 08:02 pm (UTC)
http://www.nlm.nih.gov/medlineplus/druginfo/meds/a604017.html says that progesterone can cause "abnormal clotting."

And http://www.nlm.nih.gov/medlineplus/ency/article/007111.htm says, "Doctors have long known that taking estrogen increases a person's risk for blood clots. Generally, this risk is higher if you use birth control pills, which contain high doses of estrogen. Your risk is even higher if you smoke and take estrogen. The risk is not as high when estrogen skin patches (transdermal estrogen) are used."

http://healthfinder.gov/news/newsstory.aspx?Docid=659549 says: "The review also found that women on two other forms of birth control -- the Ortho Evra patch and the NuvaRing vaginal ring from Merck -- had a higher rate of clots."

It also says, "But the absolute risk of blood clots associated with the newer pills remained relatively low, about 10 per 10,000 women, according to the University of Copenhagen researchers."

Sounds like both estrogen and progesterone can both raise the chance of blood clots (though pregnancy is worse than any HBC thus far, for increasing that risk), and newer progesterones tend to have a higher risk (though still quite small). Presumably progeterone alone has a lower risk than a combo pill.
lux_roark 2nd-Apr-2012 08:29 pm (UTC)
So I shouldn't take any birth control because of my Factor V Leiden to help control my endometriosis? I was hoping that the progestin wouldn't have a clotting factor. I really do not want to risk getting a blood clot.
disturbedme 2nd-Apr-2012 08:33 pm (UTC)
This is why I asked because I know a lot of people that have been put on progestin-only BC pills because that is all their doctor would allow when they had Factor V Leiden. Progestin-only is supposed to be safer for those who are over 35 and who smoke and those who have blood clotting issues. That is actually one of the reasons I chose progestin-only because I'm paranoid and don't want to take something with estrogen in it. I too have endometriosis and so far have liked my progestin-only and has helped the pain and bleeding.
archangelbeth 3rd-Apr-2012 12:51 am (UTC)
It sounds like you should be talking to someone who is well-read on this topic and establish what your risks are, should you be on any form of HBC. It may be that the risk would be acceptable, to try to control the endometriosis situation. It may be that you would not consider the risk acceptable.
lux_roark 3rd-Apr-2012 01:15 am (UTC)
I'm going to try to find a doctor that accepts my insurance who knows something about Factor V Leiden and then I can weigh the risks/benefits with them.
archangelbeth 3rd-Apr-2012 02:02 am (UTC)
Crossing fingers for you!!!!
atalanta0jess 2nd-Apr-2012 10:00 pm (UTC)
I believe that certain types of progesterone, including the progesterone in the patch and the ring, have higher risk of blood clot than others. My understanding is that other types of progesterone are NOT contraindicated for people with additional risk factors.
gryphonwing 2nd-Apr-2012 11:07 pm (UTC)
Yeah, there's the stuff in POPs, which is... progestrogen? Something like that. Sorta different.

nickelshoe 3rd-Apr-2012 02:16 am (UTC)
Nah, POPs use progestins that are also available in combined pills. http://en.wikipedia.org/wiki/Oral_contraceptive_formulations
Julie Heffner Mcintyre nuvaring no no22nd-Jan-2013 09:34 pm (UTC)
I was 24 when my gynecologist put m on the nuvaring to control my endometriosis. 7 months later I had a massive stroke!Nuvaring is a bad idea!
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